Tadashi Uwagawa Selected Research

Serine Proteinase Inhibitors (Serine Protease Inhibitors)

12/2019	Prevention of early liver metastasis after pancreatectomy by perioperative administration of a nuclear factor-κB inhibitor in mice.
10/2018	Nafamostat Mesilate Enhances the Radiosensitivity and Reduces the Radiation-Induced Invasive Ability of Colorectal Cancer Cells.
1/2016	Dual inhibition of nuclear factor kappa-B and Mdm2 enhance the antitumor effect of radiation therapy for pancreatic cancer.
6/2013	Combination chemotherapy of serine protease inhibitor nafamostat mesilate with oxaliplatin targeting NF-κB activation for pancreatic cancer.
2/2013	Phase II study of gemcitabine in combination with regional arterial infusion of nafamostat mesilate for advanced pancreatic cancer.
9/2011	Nafamostat mesilate can prevent adhesion, invasion and peritoneal dissemination of pancreatic cancer thorough nuclear factor kappa-B inhibition.
7/2011	Combination treatment using adenovirus vector-mediated tumor necrosis factor-alpha gene transfer and a NF-κB inhibitor for pancreatic cancer in mice.
10/2010	Anti-tumor effect by inhibition of NF-kappaB activation using nafamostat mesilate for pancreatic cancer in a mouse model.
8/2009	Combination chemotherapy of nafamostat mesilate with gemcitabine for pancreatic cancer targeting NF-kappaB activation.
5/2007	Mechanisms of synthetic serine protease inhibitor (FUT-175)-mediated cell death.

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Tadashi Uwagawa Research Topics

Disease

40	Neoplasms (Cancer) 10/2022 - 09/2004
36	Pancreatic Neoplasms (Pancreatic Cancer) 10/2022 - 06/2005
5	Biliary Tract Neoplasms (Biliary Tract Cancer) 07/2022 - 01/2015
5	Neoplasm Metastasis (Metastasis) 07/2022 - 09/2011
4	Hepatocellular Carcinoma (Hepatoma) 09/2021 - 01/2009
4	Gallbladder Neoplasms (Gallbladder Cancer) 01/2021 - 12/2008
2	Mitochondrial Diseases (Mitochondrial Disease) 10/2022 - 11/2021
2	Residual Neoplasm 07/2022 - 01/2021
2	Lymphatic Metastasis 07/2022 - 06/2019
2	Hemorrhage 11/2019 - 01/2008
2	Cholangiocarcinoma 06/2019 - 01/2018
2	Colorectal Neoplasms (Colorectal Cancer) 01/2019 - 10/2018
2	Stomach Neoplasms (Stomach Cancer) 04/2018 - 01/2013
2	Thrombocytosis (Thrombocythemia) 03/2018 - 10/2013
2	Adenocarcinoma 01/2017 - 11/2016
2	Body Weight (Weight, Body) 01/2017 - 08/2009
2	Cancer Pain 02/2013 - 12/2011
2	Pancreatic Fistula (Pancreatic Fistulas) 07/2011 - 01/2008
1	Neutropenia 04/2022
1	Thrombosis (Thrombus) 03/2022
1	Leukemia 04/2020
1	Eosinophilia 04/2020
1	Rectal Neoplasms (Rectal Cancer) 10/2018
1	Digestive System Neoplasms (Cancer of the Digestive System) 10/2018
1	Multiple Myeloma 03/2018
1	Bile Duct Neoplasms (Bile Duct Cancer) 01/2018
1	Exocrine Pancreatic Insufficiency 01/2018
1	Cachexia 01/2018
1	Duodenal Obstruction 12/2017
1	Duodenal Neoplasms (Duodenal Cancer) 12/2017

Drug/Important Bio-Agent (IBA)

22	nafamostatIBA 01/2022 - 05/2007
18	Gemcitabine FDA Link 01/2022 - 08/2009
12	NF-kappa B (NF-kB)IBA 01/2021 - 09/2004
10	Serine Proteinase Inhibitors (Serine Protease Inhibitors)IBA 12/2019 - 05/2007
5	Cisplatin (Platino)FDA LinkGeneric 06/2019 - 01/2015
4	EnzymesIBA 10/2022 - 02/2010
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 09/2013 - 05/2007
3	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 02/2013 - 09/2004
2	Fatty Acids (Saturated Fatty Acids)IBA 04/2022 - 01/2018
2	Omega-3 Fatty Acids (Omega 3 Fatty Acids)IBA 04/2022 - 01/2018
2	Small Interfering RNA (siRNA)IBA 11/2021 - 05/2007
2	Matrix Metalloproteinases (MMPs)IBA 12/2019 - 10/2018
2	Cytotoxins (Cytolysins)IBA 10/2018 - 12/2015
2	130-nm albumin-bound paclitaxelIBA 03/2018 - 11/2016
2	pomalidomideIBA 03/2018 - 03/2018
2	Pharmaceutical PreparationsIBA 03/2018 - 12/2008
2	Carcinoembryonic AntigenIBA 01/2018 - 11/2012
2	AlbuminsIBA 01/2018 - 01/2017
2	Interleukin-8 (Interleukin 8)IBA 02/2013 - 09/2011
2	Opioid Analgesics (Opioids)IBA 02/2013 - 12/2012
2	Paclitaxel (Taxol)FDA LinkGeneric 01/2013 - 05/2011
2	Caspase 8 (Caspase-8)IBA 10/2010 - 05/2007
2	Transcription Factors (Transcription Factor)IBA 06/2005 - 09/2004
1	GlucosidasesIBA 10/2022
1	SphingolipidsIBA 10/2022
1	AcidsIBA 10/2022
1	Pancrelipase (Creon)FDA Link 04/2022
1	Eicosapentaenoic AcidIBA 04/2022
1	folfirinoxIBA 03/2022
1	CeramidesIBA 11/2021
1	Acid CeramidaseIBA 11/2021
1	Reactive Oxygen Species (Oxygen Radicals)IBA 11/2021
1	Superoxide DismutaseIBA 11/2021
1	Protease Inhibitors (Protease Inhibitor)IBA 01/2021
1	Formaldehyde (Formol)FDA Link 01/2021
1	ParaffinIBA 01/2021
1	Type 2 Fibroblast Growth Factor Receptor (Fibroblast Growth Factor Receptor 2)IBA 01/2021
1	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 04/2020
1	Matrix Metalloproteinase 2 (Gelatinase A)IBA 12/2019
1	Sorafenib (BAY 43-9006)FDA Link 11/2019
1	ClaudinsIBA 01/2019
1	DNA (Deoxyribonucleic Acid)IBA 01/2019
1	Trastuzumab (Herceptin)FDA Link 04/2018
1	Capecitabine (Xeloda)FDA Link 04/2018
1	human ERBB2 proteinIBA 04/2018
1	alpha-Fetoproteins (alpha-Fetoprotein)IBA 04/2018
1	Antineoplastic Agents (Antineoplastics)IBA 03/2018
1	Thalidomide (Thalomid)FDA Link 03/2018
1	CaspasesIBA 03/2018
1	Glycogen Synthase (Synthase I)IBA 01/2018
1	ThrombomodulinIBA 01/2017
1	Thrombin FDA Link 01/2017
1	Orphan Nuclear ReceptorsIBA 01/2016
1	Macrophage Migration-Inhibitory FactorsIBA 01/2016

Therapy/Procedure

20	Drug Therapy (Chemotherapy) 04/2022 - 12/2008
12	Therapeutics 04/2022 - 12/2008
10	Combination Drug Therapy (Combination Chemotherapy) 01/2022 - 08/2009
4	Pancreatectomy 12/2019 - 08/2007
3	Adjuvant Chemotherapy 07/2022 - 06/2019
3	Radiotherapy 01/2021 - 01/2016
3	Neoadjuvant Therapy 10/2018 - 02/2015
2	Hepatectomy 09/2021 - 01/2009
2	Intra-Arterial Infusions 01/2021 - 02/2013
2	Palliative Care (Palliative Therapy) 12/2014 - 07/2010
2	Subcutaneous Injections 09/2013 - 02/2013
2	Catheters 12/2012 - 12/2011
1	Nutrition Therapy (Medical Nutrition Therapy) 04/2022
1	Lymph Node Excision (Lymph Node Dissection) 06/2019
1	Gastrectomy 04/2018
1	Jejunostomy 12/2017